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KMID : 1123920020160030563
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 3 p.563 ~ p.566
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Effects of Jingansikpung-tang Water Extract on LDH Activity of Cultured Spinal Sensory Neurons Damaged by GO
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Park Kwang-Su
Kwon Kang-Beom
Seong Eun-Kyung
Song Yung-Sun
Ryu Do-Gon
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Abstract
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To evaluate the effect of Jingansikpung-tang(JST) water extract on cultured mouse spinal sensory neuron which was inhibited by glucose oxidase(GO)-induced cytotoxicity, MTT and LDH activity assay were carried out after the cultured mouse spinal sensory neuron were pre-incubated with various concentrations of JST extract for 3 hours prior to exposure of GO. The results obtained were as follows: GO, a oxygen radical, decreased the survival rate of the cultured mouse spinal sensory neuron cells on MTT assay. JST water extract have efficacy of decreasing LDH activity increasing by GO in cultured mouse spinal sensory neuron. From above the results, it is concluded that JST water extract has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process.
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KEYWORD
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Jingansikpung-tang(鎭肝熄風湯), glucose oxidase(GO), MTT, LDH activity
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